产品名称
Ferritin heavy chain Rabbit Polyclonal Antibody
别名
FTH1; FTH; FTHL6; OK/SW-cl.84; PIG15; Ferritin heavy chain; Ferritin H subunit; Cell proliferation-inducing gene 15 protein
蛋白名称
Ferritin heavy chain
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2495
Human Swissprot No.
P02794
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P02794/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14319
Mouse Swissprot No.
P09528
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P09528
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25319
Rat Swissprot Link
http://www.uniprot.org/uniprot/P19132
免疫原
Synthesized peptide derived from the Internal region of human Ferritin heavy chain. AA range 120-170
特异性
Ferritin heavy chain Polyclonal Antibody detects endogenous levels of Ferritin heavy chain protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008],
组织表达
Expressed in the liver.
细胞定位
cell,nucleus,cytoplasm,mitochondrion,cytosol,intracellular ferritin complex,integral component of membrane,autolysosome,extracellular exosome,
信号通路
Porphyrin and chlorophyll metabolism;
功能
catalytic activity:4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.,function:Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis.,function:Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.,miscellaneous:In human liver the heavy chain is the major chain.,online information:Ferritin entry,similarity:Belongs to the ferritin family.,similarity:Contains 1 ferritin-like diiron domain.,subunit:Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
