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Fe65L Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT1688
产品名称
Fe65L Rabbit Polyclonal Antibody
别名
APBB2; FE65L; FE65L1; Amyloid beta A4 precursor protein-binding family B member 2; Protein Fe65-like 1
类别
常规抗体
基因名称
APBB2
蛋白名称
Amyloid beta A4 precursor protein-binding family B member 2
推荐应用
WB
反应种属
Human,Mouse
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
323
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=323
Human Swissprot No.
Q92870
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q92870/entry
Mouse Gene ID
11787
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11787
Mouse Swissprot No.
Q9DBR4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DBR4
免疫原
The antiserum was produced against synthesized peptide derived from human APBB2. AA range:471-520
特异性
Fe65L Polyclonal Antibody detects endogenous levels of Fe65L protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
预测分子量
83kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
amyloid beta precursor protein binding family B member 2(APBB2) Homo sapiens The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],
组织表达
Widely expressed.
细胞定位
Endoplasmic reticulum . Golgi apparatus . Early endosome .
功能
function:May modulate the internalization of beta-amyloid precursor protein.,similarity:Contains 1 WW domain.,similarity:Contains 2 PID domains.,subunit:Binds to the intracellular domain of the beta-amyloid precursor protein.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using APBB2 Antibody. The picture on the right is blocked with the synthesized peptide.

Western blot analysis of lysates from LOVO cells, using APBB2 Antibody. The lane on the right is blocked with the synthesized peptide.

Western blot analysis of the lysates from HepG2 cells using APBB2 antibody.

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