产品名称
FBP2 Rabbit Polyclonal Antibody
别名
KHSRP; FUBP2; Far upstream element-binding protein 2; FUSE-binding protein 2; KH type-splicing regulatory protein; KSRP; p75
蛋白名称
Far upstream element-binding protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8570
Human Swissprot No.
Q92945
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q92945/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16549
Mouse Swissprot No.
Q3U0V1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3U0V1
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=171137
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q99PF5
免疫原
Synthesized peptide derived from the N-terminal region of human FBP2.
特异性
FBP2 Polyclonal Antibody detects endogenous levels of FBP2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010],
组织表达
Detected in neural and non-neural cell lines.
细胞定位
Nucleus . Cytoplasm . A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites. .
功能
function:Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the KHSRP family.,similarity:Contains 4 KH domains.,subcellular location:A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites.,subunit:Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRPH1. Interacts with PARN. Also interacts with APC which is part of the apolipoprotein B mRNA editing enzyme complex. The interaction is not required for activity of the catalytic component, APOBEC1, but may confer stability on the complex.,tissue specificity:Detected in neural and non-neural cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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