产品名称
FAST Rabbit Polyclonal Antibody
别名
FASTK; Fas-activated serine/threonine kinase; FAST kinase
蛋白名称
Fas-activated serine/threonine kinase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10922
Human Swissprot No.
Q14296
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q14296/entry
Mouse Swissprot No.
Q9JIX9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JIX9
免疫原
The antiserum was produced against synthesized peptide derived from human FAST. AA range:361-410
特异性
FAST Polyclonal Antibody detects endogenous levels of FAST protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008],
组织表达
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
细胞定位
[Isoform 4]: Mitochondrion matrix . Colocalizes with mitochondrial RNA granules. .
功能
catalytic activity:ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein].,function:Fas-mediated apoptosis is characterized by FASTK-dephosphorylation and TIA-1-phosphorylation. Both are activated and FASTK-mediated TIA-1 activation play a key role in apoptosis.,PTM:Phosphorylated on serine/threonine.,similarity:Belongs to the FAST protein kinase family.,similarity:Contains 1 RAP domain.,subunit:Interacts with TIA-1.,tissue specificity:Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
