产品名称
ERF Rabbit Polyclonal Antibody
别名
ERF; ETS domain-containing transcription factor ERF; Ets2 repressor factor; PE-2
蛋白名称
ETS domain-containing transcription factor ERF
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2077
Human Swissprot No.
P50548
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P50548/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13875
Mouse Swissprot No.
P70459
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P70459
免疫原
The antiserum was produced against synthesized peptide derived from human ERF. AA range:492-541
特异性
ERF Polyclonal Antibody detects endogenous levels of ERF protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
ETS2 is a transcription factor and protooncogene involved in development, apoptosis, and the regulation of telomerase. The protein encoded by this gene binds to the ETS2 promoter and is a strong repressor of ETS2 transcription. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2015],
组织表达
Highest levels in testis, ovary, pancreas, and heart.
功能
function:Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation.,PTM:Phosphorylated by multiple kinases including probably ERK2. Phosphorylation regulates the activity of ERF.,sequence caution:The sequence differs from that shown because it seems to be derived from a pre-mRNA.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,tissue specificity:Highest levels in testis, ovary, pancreas, and heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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