产品名称
E-Ras Rabbit Polyclonal Antibody
别名
ERAS; HRAS2; HRASP; GTPase ERas; E-Ras; Embryonic stem cell-expressed Ras
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3266
Human Swissprot No.
Q7Z444
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q7Z444/entry
Mouse Swissprot No.
Q7TN89
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q7TN89
免疫原
The antiserum was produced against synthesized peptide derived from human ERAS. AA range:184-233
特异性
E-Ras Polyclonal Antibody detects endogenous levels of E-Ras protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012],
细胞定位
Cell membrane ; Lipid-anchor ; Cytoplasmic side .
功能
enzyme regulation:Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).,function:Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells.,similarity:Belongs to the small GTPase superfamily. Ras family.,subunit:Interacts with PIK3CD.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
