产品名称
Epsin 2 Rabbit Polyclonal Antibody
别名
EPN2; KIAA1065; Epsin-2; EPS-15-interacting protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22905
Human Swissprot No.
O95208
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O95208/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13855
Mouse Swissprot No.
Q8CHU3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CHU3
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=60443
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9Z1Z3
免疫原
The antiserum was produced against synthesized peptide derived from human EPN2. AA range:271-320
特异性
Epsin 2 Polyclonal Antibody detects endogenous levels of Epsin 2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
组织表达
Highest expression is found in brain. Detected at lower levels in lung and liver.
细胞定位
Cytoplasm . Cytoplasmic vesicle, clathrin-coated vesicle . In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex.
功能
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,domain:The DPW repeat domain is involved in AP-2 and clathrin binding.,domain:The NPF repeat domain is involved in EPS15 binding.,function:Plays a role in the formation of clathrin-coated invaginations and endocytosis.,PTM:Ubiquitinated.,similarity:Belongs to the epsin family.,similarity:Contains 1 ENTH (epsin N-terminal homology) domain.,similarity:Contains 2 UIM (ubiquitin-interacting motif) repeats.,subcellular location:In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex.,subunit:Binds EPS15 (By similarity). Binds AP-2 and clathrin.,tissue specificity:Highest expression is found in brain. Detected at lower levels in lung and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
