BD-PT1601

Epsin 1 Rabbit Polyclonal Antibody

EPN1; Epsin-1; EH domain-binding mitotic phosphoprotein; EPS-15-interacting protein 1

常规抗体

EPN1

Epsin-1

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

29924

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29924

Q9Y6I3

http://www.uniprot.org/uniprotkb/Q9Y6I3/entry

13854

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13854

Q80VP1

http://www.uniprot.org/uniprot/Q80VP1

117277

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117277

O88339

http://www.uniprot.org/uniprot/O88339

Synthesized peptide derived from Epsin 1 . at AA range: 140-220

Epsin 1 Polyclonal Antibody detects endogenous levels of Epsin 1 protein.

WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

85kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016],

Brain,Epithelium,Mammary gland,

Cytoplasm . Cell membrane ; Peripheral membrane protein . Nucleus . Membrane, clathrin-coated pit . Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity). .

Endocytosis;

domain:The DPW repeat domain is involved in AP2A2 and clathrin binding.,domain:The NPF repeat domain is involved in EPS15 binding.,function:Binds to membranes enriched in phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.,online information:The bubble's bend -Issue 42 of January 2004,PTM:Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation.,PTM:Ubiquitinated.,similarity:Belongs to the epsin family.,similarity:Contains 1 ENTH (epsin N-terminal homology) domain.,similarity:Contains 2 UIM (ubiquitin-interacting motif) repeats.,subcellular location:Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145.,subunit:Monomer. Binds clathrin, ZBTB16/ZNF145 and ITSN1. Binds ubiquitinated proteins (By similarity). Binds REPS2, EPS15, AP2A1 and AP2A2. Interacts with RALBP1 in a complex also containing NUMB and TFAP2A during interphase and mitosis.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.