产品名称
Ephrin-A4 Rabbit Polyclonal Antibody
别名
EFNA4; EPLG4; LERK4; Ephrin-A4; EPH-related receptor tyrosine kinase ligand 4; LERK-4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1945
Human Swissprot No.
P52798
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P52798/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13639
Mouse Swissprot No.
O08542
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08542
免疫原
The antiserum was produced against synthesized peptide derived from human EFNA4. AA range:131-180
特异性
Ephrin-A4 Polyclonal Antibody detects endogenous levels of Ephrin-A4 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. [provided by RefSeq, Jul 2008],
组织表达
Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines.
细胞定位
[Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform 2]: Secreted .
功能
function:May play a role in the interaction between activated B lymphocytes and dendritic cells in tonsils.,similarity:Belongs to the ephrin family.,tissue specificity:Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
