产品名称
Phospho-GSK3β(Ser9) (6H6) Mouse Monoclonal Antibody
别名
Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.91% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2932
Human Swissprot No.
P49841
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P49841/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/56637
Mouse Swissprot No.
Q9WV60
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WV60
Rat Gene Link
https://www.uniprot.org/uniprot/84027
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P18266
免疫原
Synthesized peptide derived from human Phospho-GSK3β(Ser9)
特异性
This antibody detects endogenous levels of Phospho-GSK3β(Ser9) at Human, Mouse,Rat
稀释度
IHC-p1:50-200 ,WB 1:1000-2000
背景介绍
The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009],
组织表达
Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney. Colocalizes with EIF2AK2/PKR and TAU in the Alzheimer disease (AD) brain.
细胞定位
Cytoplasm . Nucleus . Cell membrane . The phosphorylated form shows localization to cytoplasm and cell membrane (PubMed:20937854). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). .
功能
catalytic activity:ATP + [tau protein] = ADP + [tau protein] phosphate.,enzyme regulation:Inhibited when phosphorylated by AKT1.,function:Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin.,PTM:Phosphorylated by AKT1 and ILK1.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer (By similarity). Interacts with CABYR, MUC1, NIN and PRUNE.,tissue specificity:Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney.,
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
