产品名称
EphA7 Rabbit Polyclonal Antibody
别名
EPHA7; EHK3; HEK11; Ephrin type-A receptor 7; EPH homology kinase 3; EHK-3; EPH-like kinase 11; EK11; hEK11
蛋白名称
Ephrin type-A receptor 7
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2045
Human Swissprot No.
Q15375
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q15375/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13841
Mouse Swissprot No.
Q61772
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61772
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=171287
Rat Swissprot Link
http://www.uniprot.org/uniprot/P54759
免疫原
The antiserum was produced against synthesized peptide derived from human EPHA7. AA range:451-500
特异性
EphA7 Polyclonal Antibody detects endogenous levels of EphA7 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],
细胞定位
Cell membrane ; Single-pass type I membrane protein .
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A2, -A3, -A4 and -A5.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:Interacts with PRKCABP and GRIP1.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
