BD-PT1578

EphA3 Rabbit Polyclonal Antibody

EPHA3; ETK; ETK1; HEK; TYRO4; Ephrin type-A receptor 3; EPH-like kinase 4; EK4; hEK4; HEK; Human embryo kinase; Tyrosine-protein kinase TYRO4; Tyrosine-protein kinase receptor ETK1; Eph-like tyrosine kinase 1

常规抗体

EPHA3

Ephrin type-A receptor 3

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

2042

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2042

P29320

http://www.uniprot.org/uniprotkb/P29320/entry

P29319

http://www.uniprot.org/uniprot/P29319

29210

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29210

O08680

http://www.uniprot.org/uniprot/O08680

The antiserum was produced against synthesized peptide derived from human EPHA3. AA range:831-880

EphA3 Polyclonal Antibody detects endogenous levels of EphA3 protein.

WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

120kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008],

Widely expressed. Highest level in placenta.

[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .

Axon guidance;

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:114500].,function:Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Widely expressed. Highest level in placenta.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.