产品名称
EphA10 Rabbit Polyclonal Antibody
别名
EPHA10; Ephrin type-A receptor 10
蛋白名称
Ephrin type-A receptor 10
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=284656
Human Swissprot No.
Q5JZY3
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q5JZY3/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=230735
Mouse Swissprot No.
Q8BYG9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BYG9
免疫原
The antiserum was produced against synthesized peptide derived from human EPHA10. AA range:431-480
特异性
EphA10 Polyclonal Antibody detects endogenous levels of EphA10 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008],
组织表达
Mainly expressed in testis.
细胞定位
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 3]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:The protein kinase domain is predicted to be catalytically inactive.,function:Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Mainly expressed in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
