产品名称
Epac Rabbit Polyclonal Antibody
别名
RAPGEF3; CGEF1; EPAC; EPAC1; Rap guanine nucleotide exchange factor 3; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; EPAC 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP;
蛋白名称
Rap guanine nucleotide exchange factor 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10411
Human Swissprot No.
O95398
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O95398/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=223864
Mouse Swissprot No.
Q8VCC8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VCC8
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59326
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9Z1C8
免疫原
The antiserum was produced against synthesized peptide derived from human RAPGEF3. AA range:712-761
特异性
Epac Polyclonal Antibody detects endogenous levels of Epac protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
caution:It is uncertain whether Met-1 or Met-43 is the initiator.,domain:The DEP domain is involved in membrane localization independent from regulation by cAMP.,function:Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 DEP domain.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-GEF domain.,tissue specificity:Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.,
组织表达
Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.
细胞定位
Endomembrane system .
信号通路
Regulation of Actin Dynamics; AMPK
功能
caution:It is uncertain whether Met-1 or Met-43 is the initiator.,domain:The DEP domain is involved in membrane localization independent from regulation by cAMP.,function:Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 DEP domain.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-GEF domain.,tissue specificity:Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
