BD-PT1556

Endo180 Rabbit Polyclonal Antibody

MRC2; CLEC13E; ENDO180; KIAA0709; UPARAP; C-type mannose receptor 2; C-type lectin domain family 13 member E; Endocytic receptor 180; Macrophage mannose receptor 2; Urokinase-type plasminogen activator receptor-associated protein; UPAR-asso

常规抗体

MRC2

C-type mannose receptor 2

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

9902

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9902

Q9UBG0

http://www.uniprot.org/uniprotkb/Q9UBG0/entry

17534

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17534

Q64449

http://www.uniprot.org/uniprot/Q64449

498011

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=498011

Q4TU93

http://www.uniprot.org/uniprot/Q4TU93

The antiserum was produced against synthesized peptide derived from human MRC2. AA range:121-170

Endo180 Polyclonal Antibody detects endogenous levels of Endo180 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

167kD

-20°C/1 year

Polyclonal, Rabbit,IgG

mannose receptor C type 2(MRC2) Homo sapiens This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012],

Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.

Membrane; Single-pass type I membrane protein.

domain:C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner.,domain:Fibronectin type-II domain mediates collagen-binding.,domain:Ricin B-type lectin domain contacts with the second C-type lectin domain.,function:May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs).,online information:Endo180,PTM:N-glycosylated.,PTM:Phosphorylated.,similarity:Contains 1 fibronectin type-II domain.,similarity:Contains 1 ricin B-type lectin domain.,similarity:Contains 8 C-type lectin domains.,subunit:Interacts with C-terminal region of type I collagen/COL1A1 (By similarity). Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V.,tissue specificity:Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.