产品名称
TGF β (1F12) Mouse Monoclonal Antibody
别名
Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
蛋白名称
Transforming growth factor beta-1, TGF-β1, TGF b
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.11% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7040
Human Swissprot No.
P01137
Human Swissprot Link
http://www.uniprot.org/uniprot/P01137
Mouse Swissprot No.
P04202
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P04202
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P17246
免疫原
Synthesized peptide derived from human TGF β1 Polyclonal
特异性
This antibody detects endogenous levels of TGF β at Human, Mouse,Rat
稀释度
IHC-p1:50-200 ,WB 1:1000-2000
背景介绍
Transforming growth factor-β (TGF-β) superfamily members are critical regulators of cell proliferation and differentiation, developmental patterning and morphogenesis, and disease pathogenesis. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors.
组织表达
Highly expressed in bone (PubMed:11746498, PubMed:17827158). Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158).
细胞定位
[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix .; [Transforming growth factor beta-1]: Secreted .
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
