产品名称
Eme1 Rabbit Polyclonal Antibody
别名
EME1; MMS4; Crossover junction endonuclease EME1; MMS4 homolog; hMMS4
蛋白名称
Crossover junction endonuclease EME1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=146956
Human Swissprot No.
Q96AY2
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96AY2/entry
Mouse Swissprot No.
Q8BJW7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BJW7
免疫原
Synthesized peptide derived from Eme1 . at AA range: 250-330
特异性
Eme1 Polyclonal Antibody detects endogenous levels of Eme1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009],
组织表达
Epithelium,Placenta,
细胞定位
Nucleus, nucleolus . Recruited to regions of DNA damage in S-phase cells.
信号通路
Homologous recombination;
功能
cofactor:Magnesium.,function:Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.,similarity:Belongs to the EME1/MMS4 family.,subcellular location:Recruited to regions of DNA damage in S-phase cells.,subunit:May self-associate. Interacts with MUS81. Interacts with ERCC4 and FANCM.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
