产品名称
Elongin A1 Rabbit Polyclonal Antibody
别名
TCEB3; MSTP059; Transcription elongation factor B polypeptide 3; Elongin 110 kDa subunit; Elongin-A; EloA; RNA polymerase II transcription factor SIII subunit A1; SIII p110
蛋白名称
Transcription elongation factor B polypeptide 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6924
Human Swissprot No.
Q14241
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q14241/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27224
Mouse Swissprot No.
Q8CB77
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CB77
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q63187
免疫原
The antiserum was produced against synthesized peptide derived from human TCEB3. AA range:131-180
特异性
Elongin A1 Polyclonal Antibody detects endogenous levels of Elongin A1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008],
组织表达
Epithelium,Heart,Lung,Umbilical vein,
功能
domain:The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].,function:SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).,similarity:Contains 1 F-box domain.,similarity:Contains 1 TFIIS N-terminal domain.,subunit:Heterotrimer of an A (A1, A2 or A3), B and C subunit. The C subunit mediates the binding of the elongin BC complex to subunit A.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
