产品名称
eIF4E3 Rabbit Polyclonal Antibody
别名
EIF4E3; Eukaryotic translation initiation factor 4E type 3; eIF-4E type 3; eIF-4E3; eIF4E type 3; eIF4E-3
蛋白名称
Eukaryotic translation initiation factor 4E type 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=317649
Human Swissprot No.
Q8N5X7
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8N5X7/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66892
Mouse Swissprot No.
Q9DBB5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DBB5
免疫原
The antiserum was produced against synthesized peptide derived from human EIF4E3. AA range:141-190
特异性
eIF4E3 Polyclonal Antibody detects endogenous levels of eIF4E3 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008],
细胞定位
cytoplasm,cytosol,mRNA cap binding complex,
功能
function:Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity.,similarity:Belongs to the eukaryotic initiation factor 4E family.,subunit:eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G (By similarity). EIF4E3 interacts with EIF4G1, but not with EIF4EBP1, EIF4EBP2 and EIF4EBP3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
