产品名称
eIF4B Rabbit Polyclonal Antibody
别名
EIF4B; Eukaryotic translation initiation factor 4B; eIF-4B
蛋白名称
Eukaryotic translation initiation factor 4B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1975
Human Swissprot No.
P23588
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P23588/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=75705
Mouse Swissprot No.
Q8BGD9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BGD9
免疫原
The antiserum was produced against synthesized peptide derived from human eIF4B. AA range:388-437
特异性
eIF4B Polyclonal Antibody detects endogenous levels of eIF4B protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Self-associates and interacts with EIF3 p170 subunit.,
组织表达
Adipose tissue,Brain,Cervix carcinoma,Epithelium,Liver,Lung
细胞定位
cytosol,polysome,eukaryotic translation initiation factor 4F complex,dendrite,neuronal cell body,
功能
function:Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Self-associates and interacts with EIF3 p170 subunit.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
