产品名称
eIF2Bδ Rabbit Polyclonal Antibody
别名
EIF2B4; EIF2BD; Translation initiation factor eIF-2B subunit delta; eIF-2B GDP-GTP exchange factor subunit delta
蛋白名称
Translation initiation factor eIF-2B subunit delta
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8890
Human Swissprot No.
Q9UI10
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UI10/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13667
Mouse Swissprot No.
Q61749
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61749
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117019
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q63186
免疫原
The antiserum was produced against synthesized peptide derived from human EIF2B4. AA range:226-275
特异性
eIF2Bδ Polyclonal Antibody detects endogenous levels of eIF2Bδ protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Adrenal gland,Brain,Lung,Testis,Uterus,
细胞定位
cytoplasm,cytosol,eukaryotic translation initiation factor 2B complex,
功能
disease:Defects in EIF2B4 are a cause of leukodystrophy with vanishing white matter (VWM) [MIM:603896]. VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.,function:Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.,similarity:Belongs to the EIF-2B alpha/beta/delta subunits family.,subunit:Complex of five different subunits; alpha, beta, gamma, delta and epsilon.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
