产品名称
EFP Rabbit Polyclonal Antibody
别名
TRIM25; EFP; RNF147; ZNF147; E3 ubiquitin/ISG15 ligase TRIM25; Estrogen-responsive finger protein; RING finger protein 147; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Zinc finger protein 147
蛋白名称
E3 ubiquitin/ISG15 ligase TRIM25
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7706
Human Swissprot No.
Q14258
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q14258/entry
Mouse Swissprot No.
Q61510
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61510
免疫原
The antiserum was produced against synthesized peptide derived from human ZNF147. AA range:201-250
特异性
EFP Polyclonal Antibody detects endogenous levels of EFP protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008],
组织表达
Expressed in breast tumors (at protein level). Ubiquitous.
细胞定位
Cytoplasm . Cytoplasm, Stress granule . Nucleus .
信号通路
RIG-I-like receptor;
功能
function:Mediates estrogen action in various target organs.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 RING-type zinc finger.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
