产品名称
EF-G2 Rabbit Polyclonal Antibody
别名
GFM2; EFG2; MSTP027; Ribosome-releasing factor 2; mitochondrial; RRF2mt; Elongation factor G 2, mitochondrial; EF-G2mt; mEF-G 2; Elongation factor G2; hEFG2
蛋白名称
Ribosome-releasing factor 2 mitochondrial
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84340
Human Swissprot No.
Q969S9
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q969S9/entry
Mouse Swissprot No.
Q8R2Q4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R2Q4
免疫原
The antiserum was produced against synthesized peptide derived from human GFM2. AA range:441-490
特异性
EF-G2 Polyclonal Antibody detects endogenous levels of EF-G2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013],
功能
translation,?mitochondrion organization,?cellular component disassembly,?mitochondrial translation,?ribosome disassembly,?macromolecular complex disassembly,?ribonucleoprotein complex disassembly,?cellular macromolecular complex subunit organization,?cellular macromolecular complex disassembly,?macromolecular complex subunit organization,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
