产品名称
EDG-3 Rabbit Polyclonal Antibody
别名
S1PR3; EDG3; Sphingosine 1-phosphate receptor 3; S1P receptor 3; S1P3; Endothelial differentiation G-protein coupled receptor 3; Sphingosine 1-phosphate receptor Edg-3; S1P receptor Edg-3
蛋白名称
Sphingosine 1-phosphate receptor 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1903
Human Swissprot No.
Q99500
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q99500/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13610
Mouse Swissprot No.
Q9Z0U9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z0U9
免疫原
The antiserum was produced against synthesized peptide derived from human EDG3. AA range:115-164
特异性
EDG-3 Polyclonal Antibody detects endogenous levels of EDG-3 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008],
组织表达
Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
function:Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
