产品名称
E4BP4 Rabbit Polyclonal Antibody
别名
NFIL3; E4BP4; IL3BP1; Nuclear factor interleukin-3-regulated protein; E4 promoter-binding protein 4; Interleukin-3 promoter transcriptional activator; Interleukin-3-binding protein 1; Transcriptional activator NF-IL3A
蛋白名称
Nuclear factor interleukin-3-regulated protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4783
Human Swissprot No.
Q16649
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q16649/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18030
Mouse Swissprot No.
O08750
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08750
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114519
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q6IMZ0
免疫原
The antiserum was produced against synthesized peptide derived from human NFIL3. AA range:61-110
特异性
E4BP4 Polyclonal Antibody detects endogenous levels of E4BP4 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014],
组织表达
Expressed in bladder stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow and muscle.
功能
function:Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death.,induction:Up-regulated by PHA or TPA.,similarity:Belongs to the bZIP family. NFIL3 subfamily.,similarity:Contains 1 bZIP domain.,subunit:Homodimer. Binds DNA as a dimer. Interacts with DR1. Interacts with PER2 and CRY2.,tissue specificity:Expressed in bladder stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow and muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
