产品名称
PSMD5 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5711
Human Swissprot No.
Q16401
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q16401/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/66998
Mouse Swissprot No.
Q8BJY1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BJY1
免疫原
Synthesized peptide derived from human PSMD5 AA range: 424-474
特异性
This antibody detects endogenous levels of PSMD5 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPase subunit of the 19S regulator base that functions as a chaperone protein during 26S proteasome assembly. [provided by RefSeq, Jul 2012],
细胞定位
proteasome complex,nucleoplasm,cytosol,proteasome regulatory particle, base subcomplex,proteasome accessory complex,
功能
domain:Rich in dileucine repeats, which have been implicated in trafficking of a variety of transmembrane proteins.,function:Belongs to the 26S multisubunit protease, which is required for ubiquitin-dependent proteolysis. Does not bind ubiquitin polymers.,similarity:Belongs to the proteasome subunit S5B family.,subunit:26S protease is composed of a multicatalytic protease (proteasome) and a regulatory ATPase complex. Both are multisubunit structures that associate in the presence of ATP to form the protease. Subunit S5B is part of the regulatory complex.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
