产品名称
Dynein IC2 Rabbit Polyclonal Antibody
别名
DNAI2; Dynein intermediate chain 2; axonemal; Axonemal dynein intermediate chain 2
蛋白名称
Dynein intermediate chain 2 axonemal
反应种属
Human,Mouse,Rat,Chicken
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64446
Human Swissprot No.
Q9GZS0
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9GZS0/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=432611
Mouse Swissprot No.
A2AC93
Mouse Swissprot Link
http://www.uniprot.org/uniprot/A2AC93
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=360654
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q66HC9
免疫原
The antiserum was produced against synthesized peptide derived from human DNAI2. AA range:71-120
特异性
Dynein IC2 Polyclonal Antibody detects endogenous levels of Dynein IC2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2010],
组织表达
Highly expressed in trachea and testis. Expressed in respiratory ciliated cells (at protein level) (PubMed:33139725).
细胞定位
Cytoplasm, cytoskeleton, cilium axoneme . Dynein axonemal particle . Located in the proximal region of respiratory cilia. .
信号通路
Huntington's disease;
功能
disease:Defects in DNAI2 are the cause of primary ciliary dyskinesia type 9 (CILD9) [MIM:612444]. CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.,function:Part of the dynein complex of respiratory cilia.,sequence caution:Intron retention.,similarity:Belongs to the dynein intermediate chain family.,similarity:Contains 5 WD repeats.,subunit:Consists of at least two heavy chains and a number of intermediate and light chains. Interacts with KTU.,tissue specificity:Highly expressed in trachea and testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
