BD-PT1429

Dynein IC1 Rabbit Polyclonal Antibody

DNAI1; Dynein intermediate chain 1; axonemal; Axonemal dynein intermediate chain 1

常规抗体

DNAI1

Dynein intermediate chain 1 axonemal

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

27019

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27019

Q9UI46

http://www.uniprot.org/uniprotkb/Q9UI46/entry

68922

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=68922

Q8C0M8

http://www.uniprot.org/uniprot/Q8C0M8

500442

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=500442

Q5XIL8

http://www.uniprot.org/uniprot/Q5XIL8

The antiserum was produced against synthesized peptide derived from human DNAI1. AA range:211-260

Dynein IC1 Polyclonal Antibody detects endogenous levels of Dynein IC1 protein.

WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

79kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

Expressed in respiratory ciliated cells (at protein level).

Dynein axonemal particle . Cytoplasm, cytoskeleton, cilium axoneme .

Huntington's disease;

disease:Defects in DNAI1 are the cause of Kartagener syndrome (KTGS) [MIM:244400]. KTGS is an autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera).,disease:Defects in DNAI1 are the cause of primary ciliary dyskinesia type 1 (CILD1) [MIM:244400]. CILD1 is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.,function:Part of the dynein complex of respiratory cilia.,similarity:Belongs to the dynein intermediate chain family.,similarity:Contains 5 WD repeats.,subunit:Consists of at least two heavy chains and a number of intermediate and light chains.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.