产品名称
Dvl-3 Rabbit Polyclonal Antibody
别名
DVL3; KIAA0208; Segment polarity protein dishevelled homolog DVL-3; Dishevelled-3; DSH homolog 3
蛋白名称
Segment polarity protein dishevelled homolog DVL-3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1857
Human Swissprot No.
Q92997
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q92997/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13544
Mouse Swissprot No.
Q61062
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61062
免疫原
The antiserum was produced against synthesized peptide derived from human DVL3. AA range:326-375
特异性
Dvl-3 Polyclonal Antibody detects endogenous levels of Dvl-3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008],
组织表达
Bone marrow,Brain,Hippocampus,Placenta,Uterus,
信号通路
WNT;WNT-T CELLNotch;Melanogenesis;Pathways in cancer;Colorectal cancer;Basal cell carcinoma;
功能
function:May play a role in the signal transduction pathway mediated by multiple Wnt genes.,similarity:Belongs to the DSH family.,similarity:Contains 1 DEP domain.,similarity:Contains 1 DIX domain.,similarity:Contains 1 PDZ (DHR) domain.,subunit:Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2 (By similarity). Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
