产品名称
Dvl-2 Rabbit Polyclonal Antibody
别名
DVL2; Segment polarity protein dishevelled homolog DVL-2; Dishevelled-2; DSH homolog 2
蛋白名称
Segment polarity protein dishevelled homolog DVL-2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1856
Human Swissprot No.
O14641
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O14641/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13543
Mouse Swissprot No.
Q60838
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60838
免疫原
Synthesized peptide derived from Dvl-2 . at AA range: 670-750
特异性
Dvl-2 Polyclonal Antibody detects endogenous levels of Dvl-2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008],
细胞定位
Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol . Cytoplasmic vesicle . Nucleus . Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Interaction with FOXK1 and FOXK2 induces nuclear translocation (PubMed:25805136). .
信号通路
WNT;WNT-T CELLNotch;Melanogenesis;Pathways in cancer;Colorectal cancer;Basal cell carcinoma;
功能
function:May play a role in the signal transduction pathway mediated by multiple Wnt genes.,PTM:Phosphorylated.,similarity:Belongs to the DSH family.,similarity:Contains 1 DEP domain.,similarity:Contains 1 DIX domain.,similarity:Contains 1 PDZ (DHR) domain.,subunit:Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2 (By similarity). Interacts with DIXDC1 and Rac.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
