产品名称
HSP40 (Mix-mA) Mouse Monoclonal Antibody
别名
DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1)
基因名称
DNAJB1 DNAJ1 HDJ1 HSPF1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.33% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3337
Human Swissprot No.
P25685
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P25685/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/81489
Mouse Swissprot No.
Q9QYJ3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QYJ3
免疫原
Synthesized peptide derived from human HSP40
特异性
This antibody detects endogenous levels of HSP40 at Human, Mouse,Rat
稀释度
IHC-p1:50-200 ,WB 1:1000-2000
背景介绍
This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
组织表达
Brain,Heart,Lung,Placenta,
细胞定位
Cytoplasm . Nucleus . Nucleus, nucleolus . Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.
功能
function:Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP.,induction:By heat shock.,similarity:Contains 1 J domain.,subcellular location:Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.,subunit:Interacts with DNAJC3.,
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.