产品名称
Dsg2 Rabbit Polyclonal Antibody
别名
DSG2; CDHF5; Desmoglein-2; Cadherin family member 5; HDGC
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1829
Human Swissprot No.
Q14126
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q14126/entry
Mouse Swissprot No.
O55111
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O55111
免疫原
The antiserum was produced against synthesized peptide derived from human DSG2. AA range:401-450
特异性
Dsg2 Polyclonal Antibody detects endogenous levels of Dsg2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jan 2016],
组织表达
All of the tissues tested and carcinomas.
细胞定位
Cell membrane ; Single-pass type I membrane protein. Cell junction, desmosome.
信号通路
Arrhythmogenic right ventricular cardiomyopathy (ARVC);
功能
disease:Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia 10 (ARVD10) [MIM:610193]; also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.,domain:Calcium may be bound by the cadherin-like repeats .,function:Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.,similarity:Contains 4 cadherin domains.,tissue specificity:All of the tissues tested and carcinomas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
