产品名称
DSCR 1 Rabbit Polyclonal Antibody
别名
RCAN1; ADAPT78; CSP1; DSC1; DSCR1; Calcipressin-1; Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1827
Human Swissprot No.
P53805
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P53805/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54720
Mouse Swissprot No.
Q9JHG6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JHG6
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=266766
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q6IN33
免疫原
The antiserum was produced against synthesized peptide derived from human RCAN1. AA range:201-250
特异性
DSCR 1 Polyclonal Antibody detects endogenous levels of DSCR 1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013],
组织表达
Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.
细胞定位
intracellular,nucleus,cytoplasm,
功能
function:Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.,induction:By calcium.,similarity:Belongs to the RCAN family.,tissue specificity:Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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