产品名称
DRS-1 Rabbit Polyclonal Antibody
别名
ECI2; DRS1; HCA88; PECI; Enoyl-CoA delta isomerase 2; mitochondrial; DRS-1; Delta(3),delta(2)-enoyl-CoA isomerase; D3,D2-enoyl-CoA isomerase; Diazepam-binding inhibitor-related protein 1; DBI-related protein 1; Dodecenoyl-CoA isomerase; Hep
蛋白名称
Enoyl-CoA delta isomerase 2 mitochondrial
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10455
Human Swissprot No.
O75521
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O75521/entry
Mouse Swissprot No.
Q9WUR2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WUR2
免疫原
The antiserum was produced against synthesized peptide derived from human PECI. AA range:73-122
特异性
DRS-1 Polyclonal Antibody detects endogenous levels of DRS-1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011],
组织表达
Abundant in heart, skeletal muscle and liver. Expressed in CD34(+) T-cells and CD34(+) bone marrow cells.
细胞定位
[Isoform 1]: Mitochondrion .; [Isoform 2]: Peroxisome matrix .
信号通路
Fatty acid metabolism;
功能
catalytic activity:(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.,function:Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.,similarity:Contains 1 ACB (acyl-CoA-binding) domain.,similarity:In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.,tissue specificity:Abundant in heart, skeletal muscle and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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