产品名称
HSC70 (7G12) Mouse Monoclonal Antibody
别名
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)
基因名称
HSPA8 HSC70 HSP73 HSPA10
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.34% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3312
Human Swissprot No.
P11142
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P11142/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/15481
Mouse Swissprot No.
P63017
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P63017
Rat Gene Link
https://www.uniprot.org/uniprot/24468
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P63018
免疫原
Synthesized peptide derived from human HSC70
特异性
This antibody detects endogenous levels of HSC70 at Human, Mouse,Rat
稀释度
IHC-p1:50-200 ,WB 1:1000-2000
背景介绍
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011],
细胞定位
Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.
功能
function:Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.,induction:Constitutively synthesized.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 (By similarity). Interacts with PACRG and TSC2. Interacts with SV40 VP1.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
