产品名称
P27 Kip1 (1A7) Mouse Monoclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.35% New type preservative N.
Human Swissprot No.
P45627
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P45627/entry
免疫原
Synthesized peptide derived from human P27 Kip1
特异性
This antibody detects endogenous levels of P27 Kip1 at Human, Mouse,Rat
稀释度
IHC-p1:50-200 ,WB 1:1000-2000
背景介绍
Cyclin dependent kinase inhibitor 1B(CDKN1B) Homo sapiens This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
