BD-PT1381-DNAM-1 Rabbit Polyclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

DNAM-1 Rabbit Polyclonal Antibody

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产品基本信息

产品货号

BD-PT1381

产品名称

DNAM-1 Rabbit Polyclonal Antibody

别名

CD226; DNAM1; CD226 antigen; DNAX accessory molecule 1; DNAM-1; CD antigen CD226

类别

常规抗体

基因名称

CD226

蛋白名称

CD226 antigen

推荐应用

反应种属

Human,Mouse,Monkey

浓度

1 mg/ml

存储缓冲液

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Human Gene ID

10666

Human Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10666

Human Swissprot No.

Q15762

Human Swissprot Link

http://www.uniprot.org/uniprotkb/Q15762/entry

Mouse Gene ID

225825

Mouse Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=225825

Mouse Swissprot No.

Q8K4F0

Mouse Swissprot Link

http://www.uniprot.org/uniprot/Q8K4F0

免疫原

The antiserum was produced against synthesized peptide derived from human CD226/DNAM-1. AA range:287-336

特异性

DNAM-1 Polyclonal Antibody detects endogenous levels of DNAM-1 protein.

稀释度

WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

预测分子量

38kD

运输及保存条件

-20°C/1 year

宿主

Polyclonal, Rabbit,IgG

背景介绍

This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015],

组织表达

Expressed by peripheral blood T-lymphocytes.

细胞定位

Cell membrane ; Single-pass type I membrane protein .

信号通路

Cell adhesion molecules (CAMs);

功能

function:Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.,PTM:Phosphorylated.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with PVR and PVRL2.,tissue specificity:Expressed by peripheral blood T-lymphocytes.,

期货

现货

纯化

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunofluorescence analysis of HeLa cells, using CD226/DNAM-1 Antibody. The picture on the right is blocked with the synthesized peptide.

Western blot analysis of lysates from COS7 and K562 cells, treated with PMA 125ng/ml 30‘ , using CD226/DNAM-1 Antibody. The lane on the right is blocked with the synthesized peptide.

Western blot analysis of the lysates from HUVECcells using CD226/DNAM-1 antibody.

Western Blot analysis of COS7 cells using DNAM-1 Polyclonal Antibody diluted at 1：500

Western Blot analysis of mouse-brain cells using DNAM-1 Polyclonal Antibody diluted at 1：500

Western Blot analysis of AD293 using DNAM-1 Polyclonal Antibody diluted at 1：500