产品名称
DnaJB4 Rabbit Polyclonal Antibody
别名
DNAJB4; DNAJW; HLJ1; DnaJ homolog subfamily B member 4; Heat shock 40 kDa protein 1 homolog; HSP40 homolog; Heat shock protein 40 homolog; Human liver DnaJ-like protein
蛋白名称
DnaJ homolog subfamily B member 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11080
Human Swissprot No.
Q9UDY4
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UDY4/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67035
Mouse Swissprot No.
Q9D832
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D832
免疫原
The antiserum was produced against synthesized peptide derived from human DNAJB4. AA range:91-140
特异性
DnaJB4 Polyclonal Antibody detects endogenous levels of DnaJB4 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015],
组织表达
Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver.
细胞定位
Cytoplasm . Cell membrane . Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645.
功能
induction:By heat shock.,similarity:Contains 1 J domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
