产品名称
AMPK γ1 (5H5) Mouse Monoclonal Antibody
别名
5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.37% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5571
Human Swissprot No.
P54619
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P54619/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19082
Mouse Swissprot No.
O54950
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O54950
Rat Gene Link
https://www.uniprot.org/uniprot/25520
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P80385
免疫原
Synthesized peptide derived from human AMPK γ1
特异性
This antibody detects endogenous levels of AMPK γ1 at Human, Mouse,Rat
稀释度
IHC-p1:50-200 ,WB 1:1000-2000
背景介绍
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
组织表达
Fetal liver,Muscle,Testis,
细胞定位
nucleoplasm,cytosol,membrane,nucleotide-activated protein kinase complex,extracellular exosome,
功能
function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit.,similarity:Belongs to the 5'-AMP-activated protein kinase gamma subunit family.,similarity:Contains 4 CBS domains.,subunit:Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic regulatory subunits. Interacts with FNIP1 and FNIP2.,
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
