产品名称
DNA pol λ Rabbit Polyclonal Antibody
别名
POLL; DNA polymerase lambda; Pol Lambda; DNA polymerase beta-2; Pol beta2; DNA polymerase kappa
蛋白名称
DNA polymerase lambda
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27343
Human Swissprot No.
Q9UGP5
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UGP5/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56626
Mouse Swissprot No.
Q9QXE2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QXE2
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=361767
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q5RKI3
免疫原
The antiserum was produced against synthesized peptide derived from human DNA Polymerase lambda. AA range:451-500
特异性
DNA pol λ Polyclonal Antibody detects endogenous levels of DNA pol λ protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2010],
组织表达
Expressed in a number of tissues. Abundant in testis.
细胞定位
Nucleus . Chromosome . Accumulates at sites of DNA damage. .
信号通路
Base excision repair;Non-homologous end-joining;
功能
catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,cofactor:Manganese.,function:Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DNA polymerase type-X family.,similarity:Contains 1 BRCT domain.,subunit:Binds PCNA.,tissue specificity:Expressed in a number of tissues. Abundant in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
