BD-PT1372

DNA pol δ3 Rabbit Polyclonal Antibody

POLD3; KIAA0039; DNA polymerase delta subunit 3; DNA polymerase delta subunit p66

常规抗体

POLD3

DNA polymerase delta subunit 3

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

10714

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10714

Q15054

http://www.uniprot.org/uniprotkb/Q15054/entry

Q9EQ28

http://www.uniprot.org/uniprot/Q9EQ28

The antiserum was produced against synthesized peptide derived from human POLD3. AA range:411-460

DNA pol δ3 Polyclonal Antibody detects endogenous levels of DNA pol δ3 protein.

WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

51kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012],

Bone marrow,Brain,Duodenum,Embryonic kidney,Epithelium,Lymp

Cytoplasm . Nucleus . Partially colocalizes with PCNA and POLD1 at S phase replication sites (PubMed:11595739). Recruited to DNA damage sites within 2 hours following UV irradiation (PubMed:20227374, PubMed:22801543). .

Purine metabolism;Pyrimidine metabolism;DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Homologous recombination;

function:Required for optimal DNA polymerase delta activity.,subunit:Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with POLD2. Interacts with PCNA.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.