产品名称
IPO13 Rabbit Polyclonal Antibody
别名
Importin-13 (Imp13) (Karyopherin-13) (Kap13) (Ran-binding protein 13) (RanBP13)
基因名称
IPO13 KIAA0724 RANBP13
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.263% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9670
Human Swissprot No.
O94829
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O94829/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/230673
Mouse Swissprot No.
Q8K0C1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K0C1
Rat Gene Link
https://www.uniprot.org/uniprot/116458
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JM04
免疫原
Synthesized peptide derived from human IPO13 AA range: 484-534
特异性
This antibody detects endogenous levels of IPO13 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.[provided by RefSeq, Mar 2009],
组织表达
Expressed in fetal brain, heart, intestine and kidney.
功能
function:Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.,similarity:Belongs to the importin beta family.,similarity:Contains 1 importin N-terminal domain.,similarity:Contains 14 HEAT repeats.,subunit:Interacts with UBC9, RBM8A, eIF-1A and PAX6.,tissue specificity:Expressed in fetal brain, heart, intestine and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
