产品名称
Dlx-4 Rabbit Polyclonal Antibody
别名
DLX4; BP1; DLX7; DLX8; DLX9; Homeobox protein DLX-4; Beta protein 1; Homeobox protein DLX-7; Homeobox protein DLX-8
蛋白名称
Homeobox protein DLX-4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1748
Human Swissprot No.
Q92988
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q92988/entry
Mouse Swissprot No.
P70436
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P70436
免疫原
The antiserum was produced against synthesized peptide derived from human DLX4. AA range:61-110
特异性
Dlx-4 Polyclonal Antibody detects endogenous levels of Dlx-4 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008],
组织表达
Expressed in leukemia cells and placenta. Also expressed in kidney and fetal liver.
功能
alternative products:Additional isoforms seem to exist. Ref.8 (AAC51171) sequence may be an additional isoform,function:May play a role in determining the production of hemoglobin S. May act as a repressor.,similarity:Belongs to the distal-less homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Expressed in leukemia cells and placenta. Also expressed in kidney and fetal liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
