产品名称
Dkk-3 Rabbit Polyclonal Antibody
别名
DKK3; REIC; Dickkopf-related protein 3; Dickkopf-3; Dkk-3; hDkk-3
蛋白名称
Dickkopf-related protein 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27122
Human Swissprot No.
Q9UBP4
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UBP4/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50781
Mouse Swissprot No.
Q9QUN9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QUN9
免疫原
The antiserum was produced against synthesized peptide derived from human DKK3. AA range:111-160
特异性
Dkk-3 Polyclonal Antibody detects endogenous levels of Dkk-3 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],
组织表达
Highest expression in heart, brain, and spinal cord.
功能
function:Inhibitor of Wnt signaling pathway .,PTM:N-glycosylated.,similarity:Belongs to the dickkopf family.,tissue specificity:Highest expression in heart, brain, and spinal cord.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
