产品名称
DIO3 Rabbit Polyclonal Antibody
别名
DIO3; ITDI3; TXDI3; Type III iodothyronine deiodinase; 5DIII; DIOIII; Type 3 DI; Type-III 5'-deiodinase
蛋白名称
Type III iodothyronine deiodinase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1735
Human Swissprot No.
P55073
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P55073/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=107585
Mouse Swissprot No.
Q91ZI8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91ZI8
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29475
Rat Swissprot Link
http://www.uniprot.org/uniprot/P49897
免疫原
The antiserum was produced against synthesized peptide derived from human DIO3. AA range:17-66
特异性
DIO3 Polyclonal Antibody detects endogenous levels of DIO3 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in pregnant uterus, placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It regulates circulating fetal thyroid hormone concentrations, and thus plays a critical role in mammalian development. Knockout mice lacking this gene exhibit abnormalities related to development and reproduction, and increased activity of this enzyme in infants with hemangiomas causes severe hypothyroidism. This protei
组织表达
Expressed in placenta and several fetal tissues.
细胞定位
Cell membrane ; Single-pass type II membrane protein . Endosome membrane ; Single-pass type II membrane protein .
功能
catalytic activity:3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH(2).,function:Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.,function:Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).,similarity:Belongs to the iodothyronine deiodinase family.,tissue specificity:Expressed in placenta and several fetal tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
