产品名称
Dio-1 Rabbit Polyclonal Antibody
别名
DIDO1; C20orf158; DATF1; KIAA0333; Death-inducer obliterator 1; DIO-1; hDido1; Death-associated transcription factor 1; DATF-1
蛋白名称
Death-inducer obliterator 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11083
Human Swissprot No.
Q9BTC0
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9BTC0/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23856
Mouse Swissprot No.
Q8C9B9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8C9B9
免疫原
The antiserum was produced against synthesized peptide derived from human DIDO1. AA range:161-210
特异性
Dio-1 Polyclonal Antibody detects endogenous levels of Dio-1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle . Translocates to the nucleus after pro-apoptotic stimuli (By similarity). Translocates to the mitotic spindle upon loss of interaction with H3K4me3 during early mitosis. .
功能
disease:Defects in DIDO1 may be a cause of myeloid neoplasms.,function:Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 1 TFIIS central domain.,subcellular location:Translocates to the nucleus after pro-apoptotic stimuli.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
