产品名称
IQEC1 Rabbit Polyclonal Antibody
别名
IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein)
基因名称
IQSEC1 ARFGEP100 BRAG2 KIAA0763
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.264% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9922
Human Swissprot No.
Q6DN90
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6DN90/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/232227
Mouse Swissprot No.
Q8R0S2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R0S2
免疫原
Synthesized peptide derived from human IQEC1 AA range: 693-743
特异性
This antibody detects endogenous levels of IQEC1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
组织表达
Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis.
细胞定位
Cytoplasm . Nucleus . Cell junction, synapse, postsynaptic density . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . At steady state, may be preferentially cytosolic.
功能
function:In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.,similarity:Belongs to the BRAG family.,similarity:Contains 1 IQ domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 SEC7 domain.,subcellular location:At steady state, may be preferentially cytosolic.,subunit:Interacts with ARF6.,tissue specificity:Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
