产品名称
DHS Rabbit Polyclonal Antibody
别名
DHPS; DS; Deoxyhypusine synthase; DHS
蛋白名称
Deoxyhypusine synthase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1725
Human Swissprot No.
P49366
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P49366/entry
Mouse Swissprot No.
Q3TXU5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3TXU5
免疫原
The antiserum was produced against synthesized peptide derived from human DHPS. AA range:51-100
特异性
DHS Polyclonal Antibody detects endogenous levels of DHS protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011],
组织表达
Blood,Brain,Cervix carcinoma,Lung,
功能
catalytic activity:[eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.,cofactor:NAD.,function:Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.,pathway:Protein modification; eIF5A hypusination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the deoxyhypusine synthase family.,subunit:Homotetramer formed by a dimer of dimers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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