产品名称
ZDHHC15 Rabbit Polyclonal Antibody
别名
ZDHHC15; Palmitoyltransferase ZDHHC15; Zinc finger DHHC domain-containing protein 15; DHHC-15
蛋白名称
Palmitoyltransferase ZDHHC15
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=158866
Human Swissprot No.
Q96MV8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96MV8/entry
Mouse Swissprot No.
Q8BGJ0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BGJ0
免疫原
The antiserum was produced against synthesized peptide derived from human ZDHHC15. AA range:288-337
特异性
DHHC-15 Polyclonal Antibody detects endogenous levels of DHHC-15 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the DHHC palmitoyltransferase family. Mutations in this gene are associated with mental retardatio X-linked type 91 (MRX91). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],
组织表达
Expressed in placenta, liver, lung, kidney, heart and brain.
细胞定位
Golgi apparatus membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic density .
功能
catalytic activity:Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.,disease:Defects in ZDHHC15 are the cause of mental retardation X-linked type 91 (MRX91) [MIM:300577]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.,domain:The DHHC domain is required for palmitoyltransferase activity.,function:Palmitoyltransferase specific for GAP43 and DLG4/PSD95.,PTM:Autopalmitoylated.,similarity:Belongs to the DHHC palmitoyltransferase family.,similarity:Contains 1 DHHC-type zinc finger.,tissue specificity:Expressed in placenta, liver, lung, kidney, heart and brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
