产品名称
IREB2 Rabbit Polyclonal Antibody
别名
Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.265% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3658
Human Swissprot No.
P48200
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P48200/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/64602
Mouse Swissprot No.
Q811J3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q811J3
Rat Gene Link
https://www.uniprot.org/uniprot/64831
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q62751
免疫原
Synthesized peptide derived from human IREB2 AA range: 702-752
特异性
This antibody detects endogenous levels of IREB2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
功能
cofactor:Binds 1 4Fe-4S cluster per subunit.,function:Binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.,similarity:Belongs to the aconitase/IPM isomerase family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
